Senior ADME and Quantitative Pharmacology Director - Remote

3w3 weeks ago

Enveda

US · Full-time · $340,000 – $390,000

About this role

Join Enveda as a Senior ADME and Quantitative Pharmacology Director and help transform natural compounds into life-changing medicines. We're reinventing drug discovery by harnessing nature's intelligence, identifying new medicines four times faster than the industry standard because patients can't wait.

In this role, you'll provide strategic leadership across DMPK, clinical pharmacology, and modeling & simulation for our expanding portfolio. You will oversee DMPK and PK/PD activities from candidate nomination through clinical development, making significant contributions to integrated drug development strategy.

You'll be a key member of the AQP team, reporting to the VP, AQP, and collaborating with translational, discovery, and clinical teams. Our culture is built on creativity, collaboration, and deep respect for each other, driven by the belief that people create all value.

Enveda has achieved unicorn status following a $150 million Series D funding round and advanced our first drug candidate to Phase 1 trials. We've been recognized by Newsweek, Forbes, and Fast Company for our award-winning culture and innovation.

Requirements

Expertise in DMPK, clinical pharmacology, and modeling & simulation for drug discovery and development
Experience leading DMPK and PK/PD strategy from candidate nomination through clinical development and regulatory submission
Proven ability to drive clinical pharmacology strategy including dose finding, exposure–response modeling, and PK/PD analysis
Experience providing scientific and regulatory support for DMPK and Clinical Pharmacology sections of IND, NDA, and BLA filings
Track record of acting as subject-matter expert in interactions with FDA, EMA, and other global health authorities
Ability to integrate nonclinical ADME data into clinical development plans and support compound progression
Experience providing PK/ADME support for discovery projects to enable compound selection and optimization
Strategic and technical leadership experience in a cross-functional R&D organization

Responsibilities

Lead DMPK and PK/PD strategy across discovery and development programs, from candidate nomination through clinical development and regulatory submission
Drive clinical pharmacology strategy including dose finding, exposure–response modeling, PK/PD analysis, and risk-benefit assessment for early- and late-stage programs
Oversee PK/PD study design, analysis, and interpretation, collaborating with clinical operations, biostatistics, and regulatory colleagues
Provide scientific and regulatory support for DMPK, Clinical Pharmacology, and Biopharmaceutics sections of regulatory submissions, including IND, NDA, and BLA filings
Act as the subject-matter expert for clinical pharmacology and DMPK in interactions with FDA, EMA, and other global health authorities
Partner with translational, discovery, and clinical teams to integrate nonclinical ADME data into clinical development plans and support compound progression from pipeline to early development
Work closely with Discovery and DMPK groups to provide PK/ADME support for discovery projects, enabling informed compound selection and optimization
Provide strategic and technical leadership to the AQP function on scientific matters, combining full-time and consulting resources

Benefits

Remote-first work environment with flexible location
Full-time position with competitive compensation
Opportunity to work at a unicorn-stage biotech with award-winning culture
Be part of a team recognized by Newsweek, Forbes, and Fast Company for innovation and workplace excellence